Six-Hertz Spike and Wave Epilepsy

Thalamic lesion and epilepsy with generalized seizures, ESES and spike-wave paroxysms—Report of three cases

We report three patients, who have thalamic lesion and secondary generalized epilepsy with generalized spike wave pattern. The first two patients have unilateral perinatal lesion, one with generalized tonic-clonic seizures on awakening the other with Landau-Kleffner-like syndrome. During the course of the disease both children developed electrical status epilepticus in slow wave sleep (ESES). T...

Secondary solitary wave formation in systems with generalized Hertz interactions.

We consider a chain of monodisperse elastic grains of radius R where the grains are barely in contact. The grains repel upon contact via the Hertz-type potential, V proportional to delta(n), n > 2, where delta > or = 0, is the grain-grain overlap, delta identical with 2R-(u(i+1)-u(i)), where u(i) denotes the displacement of grain i from its original equilibrium position. This being a computatio...

Unilateral and Bilateral Cortical Resection: Effects on Spike-Wave Discharges in a Genetic Absence Epilepsy Model

RESEARCH QUESTION Recent discoveries have challenged the traditional view that the thalamus is the primary source driving spike-and-wave discharges (SWDs). At odds, SWDs in genetic absence models have a cortical focal origin in the deep layers of the perioral region of the somatosensory cortex. The present study examines the effect of unilateral and bilateral surgical resection of the assumed f...

Generation of spike wave discharges in absence epilepsy: Modulatory effects of serotonin, glutamate and glycine

An EEG-fMRI Study on the Termination of Generalized Spike-And-Wave Discharges in Absence Epilepsy

INTRODUCTION Different studies have investigated by means of EEG-fMRI coregistration the brain networks related to generalized spike-and-wave discharges (GSWD) in patients with idiopathic generalized epilepsy (IGE). These studies revealed a widespread GSWD-related neural network that involves the thalamus and regions of the default mode network. In this study we investigated which brain regions...